![]() And when pancreatic cancer cells that could not use uridine were implanted in mice, only small tumors could form, according to findings published May 17 in Nature.Ī related study, published the same day in Nature Metabolism, provided strong confirmation of the finding. ![]() In experiments involving human pancreatic cancer cells grown in laboratory dishes, they showed that when glucose was lacking, uridine became the main energy source for the cells. In the study, funded in part by NCI, an international research team showed that pancreatic cancer cells appear to have a potent strategy for overcoming this glucose deprivation: They use an alternative source of fuel, a molecule called uridine. This unruly architecture surrounding these tumors creates conditions that decrease the supply of glucose, an essential fuel source for normal and cancer cells. Tumors in the pancreas typically develop a dense, nest-like structure around them-an area often referred to as the tumor microenvironment-and they also often lack intact blood vessels. Pancreatic cancer, the study found, can readily turn to an alternate source of energy to survive when its primary source, the sugar molecule glucose, is in short supply. A new study has revealed some important information about the behavior of one of the most notorious forms of cancer.
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